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Methods Mol. Lanier, and K. Cutting edge: Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. Cella, A. Bouchon, H. Grierson, J. Lewis, C. Duckett, J. Cohen, and M. Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity. Benoit, L. Wang, H. Pabst, J. Dutz, and R. Defective NK cell activation in X-linked lymphoproliferative disease.
Bottino, S. NK cells form different types of synapses that result in distinct functional outcomes: cytotoxic, inhibitory, and regulatory. Recent studies revealed that complex integration of NK receptor signaling controls cytoskeletal rearrangement and other immune synapse-related events. However, the distinct nature by which NKp46 participates in NK immunological synapse formation and function remains unknown. Figure 2. CD2 accumulates at both activating and inhibitory synapses.
Figure 3. CD2 accumulates more frequently at inhibitory synapses than at activating synapses. Figure 4. Figure 5. Surface level of CD11a is reduced at inhibitory synapses. Discussion The clustering of receptors that occurs upon ligand binding at cell—cell contacts is usually an energy-dependent process, the basis of which is still poorly understood [25].
Image Analysis Clustering or accumulation of a receptor at the NK cell immune synapse was defined as follows. Footnotes Competing Interests: The authors have declared that no competing interests exist.
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